The general theme of my research is to elucidate the molecular regulation of metabolic processes with a focus on (chole)sterol metabolism. In this respect, my work is multidisciplinary extending beyond the physiology of metabolism to a number of relevant biological processes such as inflammation, regeneration and ageing as well as their related outcomes such as atherosclerosis. Central to my research are the relevance for human disease and the in vivo aspect, mostly comprising characterization of physiological processes with the help of mouse models. In our translational work we test concepts generated in animal models also in human patients or take a vice versa approach to understand the mechanistic basis of clinical observations with the help of animal or cell culture models.